Eph Receptors in the Immunosuppressive Tumor Microenvironment
نویسندگان
چکیده
Abstract The tumor microenvironment (TME) promotes development via complex intercellular signaling, aiding growth and suppressing immunity. Eph receptors (Eph) their ephrin ligands control cell interactions during normal development, reemerge in tumors the TME, where they are implicated invasion, metastasis, angiogenesis. Recent studies also indicate roles for Ephs immune responses by controlling with innate adaptive cells within TME. Accordingly, inhibiting these functions can promote response efficacy of checkpoint inhibition. This research highlights as potential targets to enhance immune-based therapies patients cancer.
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2021
ISSN: ['1538-7445', '0008-5472']
DOI: https://doi.org/10.1158/0008-5472.can-20-3047